| TM7SF4 | TM7SF4 (transmembrane 7 superfamily member 4), DC-STAMP (dendritic cell-specific transmembrane protein) |
| Molecule Type | Antigen Expression | Molecular Weight Min / Max |
| Non-lineage Restricted Molecule Multi-pass | Lymph Node Lung Kidney Liver Dendritic Cell |
Expression | ||||||||||||||
TM7SF4 is highly expressed in lymph nodes, lung, kidney and liver. Expression is at the low level in pancreas, bone marrow, spleen, leukocytes, peripheral blood mononuclear cells and B cells. DC-STAMP expression is in dendritic cells, in both immature and mature DCs. There is no expression in freshly isolated monocytes. | ||||||||||||||
Structure | ||||||||||||||
| MOLECULAR FAMILY NAME: Belongs to the transmembrane 7 superfamily. TM7S4 is a multi-pass 470 aa glycoprotein. It contains a signal sequence, an extracellular domain which contains 3 potential N-linked glycosylation sites and a protein kinase C phosphorylation site, 7 putative transmembrane domains and a 72 aa cytoplasmic domain contains multiple serines, 2 of which could be phosphorylation domains. MOLECULAR MASS POST-TRANSCRIPTIONAL MODIFICATION Alternative splicing yields several different isoforms by the full length has not been determined. POST-TRANSLATIONAL MODIFICATION TM7SF4 has 3 N-linked glycosylation sites and a phosphorylation site. | ||||||||||||||
Ligands | ||||||||||||||
| LIGANDS AND MOLECULES ASSOCIATED WITH TM7S4: No information. | ||||||||||||||
Function | ||||||||||||||
| Dendritic cells are unique in their ability to present antigen to naive T cells, therefore playing a central role in the iniatiation of immune responses. DC-STAMP expression is down regulated by ligation of the CD40 molecule. TM7S4 plays an essential role in TNFSF11-mediated osteoclastogenesis and is involved in inducing the expession of tartrate-reistant phosphatase in osteoclast precursors. BIOCHEMICAL ACTIVITY: No information. DISEASE RELEVANCE AND FUNCTION OF TM7S4 IN INTACT ANIMAL: No information. | ||||||||||||||
Comments | ||||||||||||||
| MOLECULAR INTERACTION- PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF TM7SF4: No information. SUBSTRATES: No information. ENZYMES WHICH MODIFY TM7SD4: No information. | ||||||||||||||
Database accession numbers | ||||||||||||||
Revised June 25, 2008
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